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February 8, 2020

Sunday Thought of the Day: What Does It Take a Champion?


Well in offering this conversation starter to myself I understood how earnestly thought inciting it was, however I'm happy that I did in light of the fact that I like to get those gerbils in my mind going around every now and then. I truly needed to dive deep into the fissure of my mind on this one on the grounds that the response to this inquiry is critical with regards to looking at achieving any kind of achievement or want. I mean nobody goes for runner up and being known as the principal failure isn't actually incredible. Reality anyway is, is that we are totally conceived victors, we each are qualified for a title trophy in our own specific manners, yet the catch is we need to go out there and hold onto it.

Presently what I'll do first to respond to this inquiry decently well, is to draw upon my own genuine encounters and perceptions so I can hand-off to you thoughts that I can by and by advocate for, that can loan some understanding to what the key to this answer is. Also, despite the fact that I don't have any titles trophies that I can show on a rack on my divider, (At least not ones that date after secondary school) I do have numerous minutes throughout my life that I have define a beneficial objective out to do and have accomplished it. Sunday Morning Quotes

Reliable hard working attitude

So what do I for one think it takes to win "titles" in our vocation and in our own undertakings? The primary thing that rings a bell is consistency. All heroes must have CONSISTENT WORK ETHIC. Champions are not medium-term victories. They are competitors who get their body in the rec center and train to drive themselves as far as possible, and when they think they have, they train some more. They are researchers who require significant investment each and every minute they have on offering a conversation starter, doing tests, concocting a theory, doing all that it takes to the detriment of rest and now and again their own lives. This is all to accomplish their genuinely necessary answers that they are not ensured to get in any case. They are specialists, gourmet specialists, craftsmen, artists, business people who spend thorough hours culminating their specialty with no guarantee of winning. However, they do it. Also, they keep on consummating their art and push their confinements until something breaks, either their will or a discriminatory constraint. No victor I am aware of ever prevailing without an unfathomable hard working attitude. They all realize the street is an incredible excursion, however they are happy to take it.

Energy

So what's straightaway? Is that it? Is it simply work, work, work, work and work some more and you'll find a good pace need to be? That is a major piece of it, however you will likewise need to work a specific route too which drives me to my next quality, PASSION. Would could it be that keeps these business visionaries, competitors, and craftsmen going at 1:00 in the first part of the day when they could simply be celebrating at the local bar to take a break? It's called energy. What's more, I imagine that each individual has this unique quality profound inside them, holding back to rise to the top on the off chance that they can just locate that "a certain something" that taps this piece of their spirit. What's more, don't imagine that you need to give the idea that you've been supported by Starbucks to show energy or excitement. Energy can be shown in an assortment of ways and it comes through accomplishing something that you love. This all by itself will be your driving vitality, the gas to your motor, that will keep up you on course through your way to progress. At the point when you love what you do, it will do much for you consequently. You will have undying confidence in what you are doing and what your identity is. You will have a feeling of assurance and certainty developed by hard working attitude. Your mind will at that point begin to direct you in an assortment of approaches to tell you the best way to enhance your productivity and to assist you with building up a decent guide to accomplishment. You don't need to know all the appropriate responses when you first begin, nobody does, yet you will find your solutions en route on the off chance that you are energetic enough about your objective. This is the foundation in rearing a champ. They can have unimaginable hard working attitude, knowledge, will, and show such a significant number of other excellent characteristics however the main concern is this: If what they are following doesn't sustain their spirit, they will never arrive at the statures of those of whom it does. Energy gives you wings as you make progress toward the top.

Condition

So you realize you have energy and you realize you have the hard working attitude, so what else do you have to turn into the following top champ? You should build up for yourself the best possible ENVIRONMENT. What's more, what I mean by that, will be that each Champion needs people around them, that either propels them, trusts in them, underpins them, mentors them, and yes even detests on them. All are moving powers in pressing the inward fastens of courage that can isolate dream from the real world. You will need a decent equalization of the great and the terrible for you to accomplish significance. Look at this portion I posted from The Art of Expressing The Human Body on the off chance that you haven't as of now to perceive what I mean. Its called "A man should continually surpass his level." Basically this extract rotates around one of Bruce Lee's students, Stirling Silliphant, who accepts he can't run any longer and that he would pass on in the event that he did. Bruce Lee reacts to that idea by saying "pass on at that point." And sure enough this remark irritated Stirling so much that he got done with running. Haters are beneficial for us in a comparable irritated manner and are an ordinary piece of the procedure. Be thankful for your haters as they can be your most prominent inspiration as you climb your own stepping stool. To the extent why you will require your supporters, well what I'll state about that will be that we are for the most part human. I've valued the past to having a solid mindset and to having the option to conquer outrageous conditions, which is an incredible declaration to my own personal growth venture, however there will be unavoidable occasions where we will have our lows. I've discovered that It's all piece of the excursion and is an essential part, since it is inside these occasions that we construct our character, characterize our motivation, and that which carries us closer to our predetermination.

Comprehend what you need

In conclusion, the last key quality, as straightforward as it might show up, it must not be ignored into this condition. What's more, that is KNOWING WHAT YOU WANT. Before any of these characteristics can start working for you, you need to comprehend what you need. I see such huge numbers of capable, smart, and remarkable people out there who simply don't have a clue what they truly desire. They have extraordinary hard working attitude, with instruction to back it up, and are enthusiastic people yet have not discovered that thing they are energetic about. Furthermore, there is the distinction, the most capable mariner will even now sink if his ship is named the Titanic. I state this since we as a whole need to find our "pontoon." The one where we realize that without a sad remnant of an uncertainty, that that is the vessel that will bring us into the guaranteed land. I have seen this again and again with individuals, individuals with so much ability and mind, who settle for not as much as what they are fit for in light of the fact that their ranges of abilities are going into a sinking ship. Regardless of whether that is a vocation they aversion or whether they are associated with one of many "make easy money" thoughts. With the influx of such a large number of up and coming business visionaries today all hoping to get notoriety or fortune, it seems many are needing to get in where they fit in, and my best exhortation is to set aside some effort to reflect and to comprehend what you need. Also, it's alright on the off chance that you don't from the outset, yet that just methods you need to do more soul looking to discover what that is, on the grounds that once you do you'll be in on the immediate street to progress.
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December 5, 2011

What will they think of next?


Who knew? In the 1960's up until the 1970's ablative stereotactic surgery was used to treat neurologic disorders and neuropsychiatric illness. This treatment was largely abandoned after the 70's due to the development of highly effective drugs to treat these problems, for example, "Levodopa" to combat Parkinson's disorder. Today there seems to be a virtual renaissance of similar techniques used to help those suffering.

The technique being employed uses high-frequency electrical deep brain stimulation (DBS) on specific targets to negate some disorders. Compared to the traditional ablative stereotactic surgery, which consists of lesions and very invasive brain surgery (irreversible), DBS is much less invasive in some respects. By applying high-frequency electrical stimulation to specific brain structures a similar (but different) effect of a lesion is essentially observed. Ever since this technique's rise in popularity (starting in the 1990's) people have the option of a "less permanent". These electrical pulses are delivered by electrodes chronically implanted into a persons brain at specific regions. The exact mechanism of action for DBS still isn't fully understood and clear, but the affects and benefits to patients are both lasting and clear.

Some of the diseases mentioned in the article include Parkinson's, Tourettes syndrome, obsessive compulsive disorder and depression. Patients receiving DBS to treat Tourettes syndrome had a >70% decrease of vocal or motor tics with disappearance of sensory urges. 35-70% of patients receiving DBS to treat OCD were benefitted by a significant reduction in obsessive and compulsive thoughts.

In my opinion, and it seems to be the case with most neurosurgical operations, DBS is the latest and greatest treatment available. Anytime patients can avoid a permanent/irreversible effect such as a lesion the better. My reasoning behind is vast. For example if a patient is suffering from body dissociation disorder and doesn't identify with their right arm and right leg and wants to have these two limbs removed. This persons could amputate these limbs without fully understanding the long term consequences involved or even without any benefit mentally. Or perhaps, the doctor could try a different technique, such as lesioning a brain region located using fMRI thought to be triggering body dissociation disorder. There is a chance the lesion might not properly treat the disorder or not treat it at all. Also the lesion may impair the individual in a more negative way in the long run, and since lesions are practically irreversible, the person is worse off. If DBS was used (tmi could be used as a pre-emptive mapping tool) the patient could be treated for their disorder in a non permanent way and avoid negative, unforeseen, long term issues.

I'm not entirely sure how invasive DBS is but the article made it out to be much less invasive as previous surgeries. Which to me makes sense since over time medical practices should become more and more efficient. Something haunts me about the fact little is truly known and fully understood about DBS and TMI. Little red flags go up in my head every time that fact is mentioned. Whether or not it is effective and beneficial I would prefer to know exactly why it is effective and beneficial before doctors implanted electrodes in my brain to deliver pulses of high-frequency electricity. This honestly sounds like something out of a science fiction story but the real freaky part is it seems to actually work. The big question is: Would you ever have DBS performed on yourself? My answer is yes.

http://www.sciencedirect.com/science/article/pii/S089662730600729X
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December 3, 2011

Deep Brain Stimulation - A Different Approach


Let's talk about Parkinson's Disease (PD). PD is one of the most prevalent neurodegenerative disorders in the world for people over the age of fifty; as the population has aged and people have started living longer, PD diagnosis has increased significantly. Some of the symptoms include tremor (shaking), akinesia (inability to initiate movement), muscle rigidity, and later in the progression of the disease, slowed speech, blank staring, and dementia. So there are motor and cognitive problems associated with PD, but this post will deal with the reduction of the earlier-onset motor symptoms.

There are two main types of treatment for PD motor symptoms: drugs and deep brain stimulation (DBS). The drugs usually have a compound called L-Dopa, which is a precursor in the formation of the neurotransmitter dopamine, the lack of which has been implicated in inducing the motor symptoms of PD.

The other treatment, DBS, can only be used on some patients, namely those for whom the drugs have had little to no effect and who are also healthy enough to undergo surgery and stay alive for longer than a few years. What they do is create an open-loop (i.e. not a closed circuit) by surgically inserting an electrode into a specific region of the brain, which is connected to a pacemaker-type device called a pulse generator (IPG) that they insert below the neck. Doctors then set the IPG to a certain frequency, so the electrode will send out electrical signals into the brain every so often, and this has been shown to reduce the motor symptoms of PD.

The whole process takes up to a year, with the surgery and adjustments to the properties of the stimulation being continuously modulated until the motor symptoms are reduced and the side effects of the stimulation are not too severe. But, since PD is a progressive disease, the motor symptoms will continue getting worse and the DBS stimulation will continue to need adjustments more and more frequently as the disease progresses.

The issue with this is that no one really knows why DBS works, so all of the adjustments are guesses (systematic guesses, but guesses nonetheless) and patients need to keep coming into the hospital, which costs a lot of money, time, and frustration when their symptoms are not relieved. This is where research in the "closed-loop," or real-time adaptive, DBS comes in. This potential form of DBS also involves a chip that is used to record when natural electrical signaling occurs in the brain region the DBS electrode is in. The recording then sets the properties of the DBS stimulation on the IPG and sets a timer for when the electrode will deliver that stimulation, producing a feedback loop, and decreasing the need for the constant hospital visits.

One study found that given some specific criteria for the wait-time and the number of stimulations, some PD symptoms were reduced (namely akinesia) to a greater extent than with open-loop DBS. However, the study also found many problems with using closed-loop rather than open-loop DBS to alleviate motor symptoms, but these problems have to do with what actually causes the motor problems associated with PD. As such, the study concludes that with more research on the efficacy of closed-loop DBS and on the details of the cause of PD motor symptoms, closed-loop DBS could be used as a potential treatment for PD that will produce not only a more significant reduction of motor problems, but will also enhance the long-term efficacy of using DBS as PD progresses.

Rosin, B., Slovik, M., Mitelman, R., Rivlin-Etzion, M., Haber, S. N., Israel, Z., . . . Bergman, H. (2011). Closed-loop deep brain stimulation is superior in ameliorating Parkinsonism. Neuron, 72(2), 370-384. doi:10.1016/j.neuron.2011.08.023 Retrieved from http://www.cell.com/neuron/abstract/S0896-6273%2811%2900776-8
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