Create an Account CourseStreet Log in  Connect with Facebook
Home Blog
 

NRSC 2100 Blog

A GROUP WEBLOG FOR NRSC 2100 SUMMER NRSC 2100

Showing entries tagged bipolar.  Show all entries

March 14, 2020

Mod Skin LoL Pro 2019 Download


Just want to share the free mod skin lol challenger avatar generator that I was able to create, you might want to try it out, you'll get the chance to choose and create your own avatar, it's very easy and anytime you wanted to change you don't have to pay and spend a single cent.
Posted by      Glenn E. at 3:00 AM MDT
displaying most recent comments (4 ommitted) | Comments (7)
  ali poors  says:
shakhmusic
Downloading Iranian and foreign update songs is one of the advantages of Persian language sites that are able to provide up-to-date Iranian and foreign music. According to the tastes of our music friends,
Posted on Wed, 29 Apr 2020 6:43 PM MDT by ali p.
  hulu SUPPORT  says:
Activatehulu.com help you to activate your hulu. you can watch hulu shows online. enter your hulu activation code on hulu com activate or www.Hulu.com/Activate are related words for hulu activation.
check out Hulu News for latest hulu activation news
Posted on Thu, 14 May 2020 2:21 PM MDT by hulu S.
  ritcha filter far  says:
Thanks for sharing such good information.slotxo
Posted on Thu, 14 May 2020 9:33 PM MDT by ritcha f.

December 2, 2011

One gene to ruin them all: schizophrenia, bipolar, and DISC1


Discovered over a decade ago by scientists studying a Scottish family riddled with mental disorders, variations in the gene DISC1, or "discovered in schizophrenia-1", have been heavily linked to development of schizophrenia and, to a lesser extent, bipolar disorder. Only recently, however, have scientists begun unraveling the importance of the gene and its mechanistic functions. DISC1 encodes a scaffolding protein, a protein whose function is to help organize signaling pathways via formation of complexes with multiple other proteins in a way that allows them to interact. Experiments have shown the critical importance of DISC1 in a multitude of developmental functions, including neuronal migration, axonal and dendritic growth, and synaptogenesis, and neurogenesis, to name a few. Of the half-dozen or so DISC1-dependent signaling pathways discovered, a recent paper shows that disruptions in the Wnt pathway is implicated in a significant amount of the abnormal neurological features seen in persons with schizophrenia (and bipolar).

The Wnt pathway is critical for cell proliferation during development and plays key roles in embryogeneis, neuronal growth, and certain types of cancer. Activation of this pathway results in an increase of B-catenin, which associates with other proteins to upregulate transcription of certain genes necessary for proper neuronal development. Recent experiments have showed that schizophrenics and bipolar patients with genetic variations of the DISC1 gene show inhibited Wnt signaling and reduced neuroblastoma (N2a) cell proliferation. These studies also showed that the most common DISC1 variants had a decreased affinity for the protein GSK3-B, an intermediate in the Wnt pathway, to which it normally binds and inhibits. GSK3-B is responsible for the phosphorylation and subsequent degradation of B-catenin in the absence of Wnt signaling, and it is thought that in the absence of Wnt DISC1 is responsible for its inhibition. Since schizophrenic variations of DISC1 show a decreased affinity for GSK3-B, this may suggest a mechanism for the reduced signaling seen in many areas of the schizophrenic brain.

So why does any of this matter? Drug treatments. Lithium, the classic mood-stabilizing drug used to treat mania, was shown to inhibit GSK3-B just a little over a decade ago, and its mechanism of action is only now coming to light. Some antipsychotics have also been shown to indirectly stimulate the Wnt pathway, which might be a significant aspect of their pharmacological actions. With this knowledge in hand, selective inhibitors of GSK3-B (mimicking the actions of DISC1) or agonists for Frizzled, the Wnt receptor, could effectively attenuate many of the symptoms associated with schizophrenia and bipolar disorder. Along with brain imaging and genetic testing, disruptions in this pathway could also serve as an early marker for children predisposed for these mental disorders. Drugs such as those mentioned above could also prove useful in children with a high risk for developing schizophrenia or bipolar, in which an early drug regiment could blunt the onset of the disease and possibly prevent a lifelong struggle with a mental disorder. Although there are many other genes and pathways implicated in these cognitive disorders, the massive developmental impact of DISC1 variants and their effects on the Wnt pathway opens up promising new therapeutic opportunities for the treatment of schizophrenia and bipolar disorder.

Paper: "Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development", Singh et. al

http://www.sciencedirect.com/science/article/pii/S0896627311008841
Posted by      Kevin K. at 4:43 PM MST
displaying most recent comments (3 ommitted) | Comments (6)
  charlly korpa  says:
You have shared a piece of valuable information that everyone should know. There are some people already having this illness. Of course, they can control this illness. Could you please share the treatment for schizophrenia and bipolar also? Hostsailor
Posted on Mon, 20 Jan 2020 11:45 PM MST by charlly k.
  leona margret  says:
hai

[url=https://www.google.com]nice![/url]
Posted on Wed, 22 Jan 2020 9:16 PM MST by leona m.
  milan joy  says:
From this post, i came to know in detail about this disease form called schizophrenia. This article check this out tells more regarding that and i understand the critical faces of this disease from here. I am looking for more updates from here and keep up the good work.
Posted on Thu, 20 Feb 2020 11:48 AM MST by milan j.




 Copyright © 2007-2016 Don Cooper, Ph.D.. All rights reserved.
  Feed — Subscribe: RSS