CBDO13 9012

Instructor:

Steve Jacobs

Email: steve@bondihempoil.com.au

How do endocannabinoids from CBD oil work? The discovery of cannabinoid receptors suggested that There are endogenous substances that attach to these receptors. The first endogenous to be detected in 1992 Cannabinoid anandamide or Arachidonoylethanolamide (AEA) is an amide of Arachidonic acid, the second, discovered in 1995, Endocannabinoid 2-arachidonoylglycerol (2-AG), an ester from arachidonic acid and glycerol. It was in the episode a variety of other anandamide-like compounds discovered that so far, however, mostly not yet or are hardly explored. Endocannabinoids work in several ways. The best known is that of the so-called retrograde - reverse - inhibition of activity other neurotransmitters, messenger substances in the nervous system. In contrast to most neurotransmitters' endocannabinoids are not produced by the nerve cells - that is, they don't Transmit signals to other nerve cells, but from the one receiving the signal. The endocannabinoid system is "Tonic active" (from the Greek tonus, "tension"). Above all, when the signal between the two nerve cells involved strong, i.e., the concentration of other messenger substances is high, the formation of endocannabinoids is increased, which is how the activation of cannabinoid receptors helps reduce excessive Neurotransmitter activity.

How do endocannabinoids from CBD work?For a number of diseases, the concentration of endocannabinoids is increased because the Body tries to heal itself as part of the process to combat symptoms of illness. This is the case, for example for Tourette syndrome. On the other hand, some see Diseases caused by an endocannabinoid deficiency including migraines, fibromyalgia, and irritable bowel syndrome. For this purpose, the term endocannabinoid deficiency was coined. The body produces these compounds to deal with Diseases and it may be due to hereditary factors. Plants have few endocannabinoids. Different endocannabinoids cannot bind with cannabinoid receptors, but also to the GPR55 receptor (G protein coupled receptor 55) and similar binding sites (GPR119, GPR18) as well as to the Vanilloid receptors of type 1 and type 2. More binding sites for Endocannabinoids such as the PPAR gamma (peroxisome Proliferator-activated receptor gamma), are located on the outside of the cell or the cell membrane. Therefore, over the last few years the image of an endogenous Cannabinoid system consisting of two Cannabinoid receptors (CB1 and CB2 receptors) as well as two Endocannabinoids (anandamide and 2-AG) has fundamental changed. CBD oil triggers each of these receptors in turn but does not discriminate.

As we are dealing with a complex system it has many functions in health and disease. The exact structure of CBD was identified in 1933. The first Endocannabinoid (anandamide) was uncovered from Cannabinoid research that has been very exciting and that the next 50 years will probably be no less will be exciting. Less well-researched endocannabinoids-such as anandamide-like substances were only recently discovered in the brain. Only a few have so far had their Effects investigated. After examining the cannabinoids and their effects, research into the endocannabinoid system is now beginning to pick up rapidly. Endocannabinoid-like substances studied could have been quite different pharmacological Effects and benefits when triggered from CBD oil. Here are some examples: Arachidonoyl serine has vasodilatory properties and has a nerve protective effect. Its effect seems to be indirect the CB2 receptor to be mediated. Others can bind to the CB1 Receptor and causes sedation, reducing Body temperature and bowel movements as well as providing Pain relief.

Do endocannabinoids benefit the brain?Virodhamin (O-arachidonoylethanolamide, OAE) blocks the activity of the CB1 receptor. Oleoylserine shows effects against osteoporosis. Oleoylethanolamide regulates food intake and body weight. It However, it is becoming apparent that the mode of action of many Endocannabinoid-like substances goes beyond what we have researched well in the past. Functions of the endocannabinoids is both in the central nervous system as well as in peripheral organs and tissues that impact physiological functions, including in the cardiovascular System, in the gastrointestinal tract, in the liver, in the Immune system, in the muscles, the bones, the Reproductive organs and skin. There must be a reason give why our bodies contain so many different Endocannabinoids and endocannabinoid-like substances. We can speculate whether different concentrations of endocannabinoids with differing physiological and psychological Effects in the brain are partly responsible for different personality types potentially.

The effects of endocannabinoids on the brain will be mainly mediated via CB1 receptors, but partly also via CB2 receptors. One of the most important functions of the endocannabinoid system in the brain is the regulation of a system that is used to cope with stress. It plays a role in anxiety and depression as well the formation of new nerve cells. It works on that Reward system of the brain and thus has an influence on addiction to drugs, our craving for sweets and other dependent behaviour (gambling addiction, etc.) - CBD may assist with each of these facets. The Endocannabinoid system affects our mental Performance, the ability to learn and the memory. In this context it may help deal with unpleasant memories in the therapy of post-traumatic stress disorder. Memory loss could occur in old age by activating the endocannabinoid system. For example, mice that did not have CB1 Receptors possess faster age-dependent deficits in mental performance than normal mice. They also lost important nerve cells in the hippocampus, a central brain region, suggesting inflammation of the brain cells was reduced.

CBD for pain relief - high potentialThese findings suggest that CB1 receptors in the hippocampus Can protect against a decline in mental performance. About 20 cannabinoids belong to the Delta-9-THC type, of those in the plant are mainly two delta-9-THC acids occur under the action of heat and at long storage in the phenolic delta-9-THC (Dronabinol). That phenolic THC causes the well-known psychoactive and most medicinal effects of THC-rich cannabis strains. THC binds to the two cannabinoid receptors CB1 and CB2. If the CB1 receptor is activated by phenolic THC, it leads to pain relief, muscle relaxation, Increase in appetite, expansion of the bronchi, increase heart rate, lowering blood pressure while standing, possibly to the point of fainting, widening of blood vessels with reddening of the Eyes, reduction of the pupillary response to light, euphoria and other psychological effects (sedation, Anxiety), psychomotor impairment, changed time perception, reduced attention, reduced production of saliva and tear fluid, slowed gastric emptying, effects on various hormones such as cortisone and Hormones that affect appetite (ghrelin and leptin), and lowering intraocular pressure. Activation of the CB2 receptor on immune system cells by THC inhibits inflammatory processes and allergic reactions, by using inflammatory messenger substances (cytokines) reduced. CBD oil is truly remarkable in its interactions with the brain and body, in addition to the highly beneficial effects it produces.